At the age of 21, she received grants from the National Taipei University of the Arts to pursue her professional career in Europe, and was offered a contract from Tanztheater München. The next year, she joined NDT2. In 2010, Meng-Ke won the Best Dancer Award and the Audience Award at the International Solo-Dance-Theatre Festival Stuttgart.

She was promoted to NDT1 by the Artistic Director in 2013, and received a life tenure later on. During her time in NDT, she has worked with Jirí Kylián, Ohad Naharin, Mats Ek, Sol León and Paul Lightfoot, Crystal Pite, Gabriela Carrizo and Franck Chartier, Marco Goecke, Sharon Eyal and Gai Behar, Hofesh Shechter. During her tenure at NDT, her topnotch performance won the hearts of the audience and Dutch media.

In 2012, Het Parool said the "dazzling Wu takes the spotlight" in performing Kylián's Sleepless. In 2016, in a performance dedicated for the Dutch Queen, the duet with Dutch dancer Marne van Opstal received high praise from a Dutch dance magazine, which described it as a delicate and fluid interpretation. In 2017, The Times noticed “the remarkable Meng-Ke Wu” from her performance in the Edinburgh International Festival. In 2019 she was selected as outstanding performance female dancer in Dance Europe Magazine. In 2020, she participated in the Norwegian art film American Moth, opening up more dance, drama, theater performing possibilities. In 2021, she participated in the modern dance " Entropy " as a rehearsal director. In 2022, she is appointed as a guest professor of the Beijing Normal University.

Since 2022, Wu Mengke has been invited to serve as the cocurator of the Nowness Genius Program, creating a new dance video curating unit - # Move a Movie #. The aim of this unit is to allow more people to create and interpret dance images in their own ways. On 22nd July, 2023: Dance drama Poetic Dance: Dongpo , directed by Shen Wei and starring Su Peng and Wu Mengke, premiered at the Shanghai Culture Square.

After years of accumulation, in 2024 Meng-ke Wu and Yin Fang initiated the first Move to Move International Dance Festival as founders. This festival brings together top dance companies, artists, and dancers from seven countries, presenting cutting-edge and highly influential works to the audience in Aranya, Qinhuangdao, from September 14 to 17. In October of the same year, she made her theatrical debut at the Wuzhen Theatre Festival, playing the lead role of "Polly" in the play “ The Threepenny Opera ”, directed by Li Jianjun.